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Exosomes: An Active Ingredient in Cosmetics

Exosomes Active Ingredients in Cosmetics
  • October 19th, 2022
  • Blog

The skin is an important organ that not only acts as a barrier against external stimuli, but also serves in the synthesis, processing, and metabolism of structural biomolecules.

Exosomes can carry information to both local and distant cells since they circulate through body fluids. As a result, exosomes are being evaluated as a potential active principle in a variety of treatments. Stem cell-derived exosomes have recently been shown to be effective in skin problems such as ageing, atopic dermatitis (AD), and wound healing. Furthermore, exosomes are being researched for use as ingredients in commercialised skin-care products.

Role of Active Ingredients in Cosmetics

An active ingredient is any component of a drug product that is intended to offer a pharmacological activity or another direct impact on the diagnosis, cure, reduction, treatment, or disease prevention or to influence the structure or functionality of the human or animal body.

Recent research has shown that exosomes have various favourable features for skin tissue regeneration, including angiogenic capability, collagen formation, and inflammatory management. As a result, we can say that employing exosomes as a component can overcome the current inadequacies of skin treatments.

Exosomes are small extracellular vesicles that are produced from cells when the multivesicular body (MVB), an intermediate endocytic compartment, fuses with the plasma membrane. They are considered to provide a route of intercellular communication and macromolecule transmission between cells, facilitating the transfer of proteins, lipids, mRNA, miRNA, and DNA, as well as playing a role in the development of various diseases. Exosomes can carry biomolecules such as proteins, DNA, and RNA in this way. As a result, based on the cell type, we can generate exosomes with diverse therapeutic properties.

Application of Exosomes

The skin is an essential organ that not only acts as a protective barrier against external variables, but also plays a role in the formation, processing, and metabolism of basic biomolecules. Skin traumas, such as persistent wounds, flap necrosis, and inflammatory skin diseases, can impair the skin’s capacity to repair.

  • Skin Repair & Regeneration Stem cell exosomes are a new bioactive molecule that plays a role in a variety of cellular and biochemical processes in the skin. In fact, skin wound healing is partially dependent on intercellular interaction via exosomes between different skin cells. Greater knowledge of the function of exosomes in dermatology, on the other hand, will contribute to the creation of cell-free treatments for skin regeneration and healing.
  • Anti-Ageing Exosomes’ effects on skin conditions have been intensively researched in recent years. The key advantages are their excellent stability, lack of immunological rejection, and direct activation of target cells. Exosome-contained miRNAs, in particular, play a role in the post-transcriptional control of diverse cellular responses. As a result, exosomes, as a single substance, can have various therapeutic effects on skin ageing.

Exosome Advancells has developed a dynamic range of stem cell-derived exosomes for use as an active ingredient in cosmetic formulations. Get in touch with us at info@advancells.com to know more about our product.